AlphaFold DB · AF-Q99497-F1
A 189-residue (amino acid) human protein that senses oxidative stress in your cells — and whose loss causes an inherited, early-onset form of Parkinson's disease.
Loading real coordinates — not a recreation.
DJ-1's signature trick: three cysteines act like a chemical smoke detector for oxidative stress. Click one, then step through what happens to it.
All 189 residues. Confidence shading appears once the structure finishes loading. The three sensor cysteines are outlined — click them too.
hover/click any residue to sync with the 3D view and the panel above — arrow keys work too
Select an arginine (Arg / R) or cysteine (Cys / C) residue above to see its full side chain structure here.
Nothing selected yet — try residue 5 (Arg) or 46 (Cys).
Most AlphaFold entries are abstract until you connect the fold to a consequence. DJ-1 is a good one to learn on: it's small enough to hold in your head, its job (mop up reactive byproducts of metabolism before they damage other proteins and DNA) is concrete, and the cost of it failing is well documented — mutations in PARK7 are a known, if rare, cause of autosomal-recessive early-onset Parkinson's disease, often before age 40.